Many months after their war with a rogue group of Inhumans, the team is still reeling. Coulson is again trying to put the pieces of his once revered organization back together while also dealing with the loss of his hand. His confidante and second in command, Agent Melinda May, has yet to retu from an impromptu vacation with ex-husband Andrew; deadly superspy Agent Bobbi Morse is recovering from her traumatic torture at the hands of Grant Ward; Fitz is obsessed with discovering the truth behind the mysterious disappearance of Simmons; and all are on high-alert for the next move from Ward and Hydra.